Born in Rome in 1983, she studied at the conservatoires of Milan and Paris, IRCAM, and Harvard University with Alessandro Solbiati, Frédéric Durieux, and Chaya Czernowin.
She was a resident fellow of the Berliner Künstlerprogramm des DAAD in 2013, Villa Médicis (French Academy in Rome) in 2018–19, and the recipient of several prizes including the Ernst von Siemens Composition Prize and Hindemith Award in 2018, Una Vita nella Musica – Giovani (2019), and Bestenliste der Deutschen Schallplattenkritik for her first portrait CD A Failed Entertainment (2016). 

Recent commissions include works written for Arditti Quartet, Trio Catch, Quatuor Diotima, Ensemble Intercontemporain, Ensemble 2e2m, JACK, Klangforum Wien, Neue Vocalsolisten Stuttgart, Münchener Kammerorchester, Nikel, and WDR Orchestra, among others. 

Since 2014, Iannotta has been the artistic director of the Bludenz Days of Contemporary Music. Her music is published by Edition Peters. She lives and works in Berlin. 

Selected works: siciliana miniatura for string trio (2009), Al di là del bianco for bass clarinet and string trio (2009), il colore dell’ombra for piano trio (2010), Limun for violin and viola plus two people for turning pages (2011), àphones for 17 musicians (2011), clangs for cello and 15 musicians (2012), d’après for seven musicians (2012), A failed entertainment for string quartet (2013), The people here go mad.They blame the wind for bass clarinet, cello, piano and 12 music boxes (2013–14), intent on resurrection – spring or some such thing for 17 musicians (2014), 3 sur 5 for two percussionists and accordion (2012–15), troglodyte angels clank by for 13 amplified instruments and objects (2015), dead wasps in the jam-jar II for orchestra (2016), paw marks in wet cement II for piano and amplified instruments (2015–18), skull ark, upturned with no mast for four performers, installations, lights, motion, objects and electronics (2017–18), dead wasps in the jam-jar III for prepared string quartet (2017–18), Outer Space, interactive work for ensemble with electronics (2018), MOULT for orchestra (2018–19), Eclipse plumage for piano, flute (plus objects), bass clarinet (plus objects), violin, viola and cello (2019), You crawl over seas of granite for amplified string quartet (2019–20).